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Acid-Amine Coupling

Using DCC

Using EDCI

Using T3P

Using HBTU

Using HATU

Using TBTU

Using BOP

Using py.BOP

Using Mukaiyama reagent

Using NHS esters




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  • Acid to Alcohol (Acid activation & NaBH4 reduction)
  • Acid to Alcohol using NaBH4, I2
  • Acid to Amide (acid anhydride, followed by amine)
  • Acid to Amide (acid chloride, followed by amine)
  • Acid to Amide (Esterification, followed by amine)
  • Acid to Ester (Fischer Esterification)
  • Acid to Ester (SOCl2 & alcohol)
  • Acid to Ester (Steglich Esterification) - for t-butyl ester
  • Acid to Ester [(COCl)2 & alcohol]
  • Acid to Ester using Me2SO4 (for methyl ester)
  • Acid to Ester using MeI, base (for methyl ester)
  • Acid-Amine Coupling
  • Acid-Amine Coupling using BOP
  • Acid-Amine Coupling using DCC
  • Acid-Amine Coupling using EDCI
  • Acid-Amine Coupling using HATU
  • Acid-Amine Coupling using HBTU
  • Acid-Amine Coupling using Mukaiyama Reagent
  • Acid-Amine Coupling using NHS Esters
  • Acid-Amine Coupling using PyBOP
  • Acid-Amine Coupling using T3P
  • Acid-Amine Coupling using TBTU
  • Acid-Amine Coupling using TSTU
  • Alcohol to Aldehyde/Ketone using Corey-Kim Oxidation (DMSO, NCS)
  • Alcohol to Aldehyde/Ketone using Dess-Martin Periodinane (DMP)
  • Alcohol to Aldehyde/Ketone using Manganese Dioxide
  • Alcohol to Aldehyde/Ketone using Parikh–Doering oxidation (DMSO, py.SO3)
  • Alcohol to Aldehyde/Ketone using PCC (Pyridinium Chlorochromate)
  • Alcohol to Aldehyde/Ketone using PDC (Pyridinium Dichromate)
  • Alcohol to Aldehyde/Ketone using Pfitzner-Moffatt Oxidation
  • Alcohol to Aldehyde/Ketone using Swern Oxidation
  • Alcohol to Aldehyde/Ketone using Swern Oxidation variant (DMSO, TFAA)
  • Alcohol to Azide using DPPA
  • Alcohol to Bromide using HBr
  • Alcohol to Bromide/Chloride/Iodide using Appel reaction
  • Alcohol to Carboxylic acid using Jones Reagent
  • Alcohol to Carboxylic acid using NaClO, TEMPO
  • Alcohol to Carboxylic acid using NMO, TPAP
  • Alcohol to Chloride using Cyanuric chloride
  • Alcohol to Chloride using Thionyl Chloride
  • Alcohol to Ester using Fischer Esterification
  • Alcohol to Ester using Steglich Esterification
  • Alcohol to Ether using Williamson synthesis (O-Alkylation)
  • Alcohol to Fluoro / Carbonyl to Difluoro using DAST
  • Alcohol to Fluoro / Carbonyl to Difluoro using Deoxofluor (BAST)
  • Alcohol to Mesylate using MsCl, base
  • Alcohol to Methylene (Deoxygenation) using Et3SiH, TFA
  • Alcohol to Tosylate using Tosyl Cl, base
  • Alcohol to Triflate using Tf2O, base
  • Aldehyde to Alcohol using DIBAL-H reduction
  • Aldehyde to Alcohol using NaBH4 reduction
  • Aldehyde/Ketone to Alkene (Schlosser Modification of Wittig reaction)
  • Aldehyde/Ketone to Alkene (Tebbe Olefination)
  • Aldehyde/Ketone to Alkene (Wittig & Wittig-Horner reaction)
  • Aldehyde/Ketone to Alkyne (Corey-Fuchs reaction & n-BuLi)
  • Amide hydrolysis under basic condition
  • BH3.Me2S (BMS reduction) reduction of Acids & Amides
  • BH3.THF (Borane THF) reduction of Acids & Amides
  • Buchwald-Hartwig Coupling
  • C-C Bond Formation
  • Cross-Coupling Reactions
  • Cross-Coupling Reactions - Back-up details
  • Deoxygenation of Aldehyde/Ketone (Clemmensen reduction)
  • Deoxygenation of Aldehyde/Ketone (Thioacetal & reduction)
  • Deoxygenation of Aldehyde/Ketone (Wolff-Kishner reduction)
  • Ester Hydrolysis under acidic condition
  • Ester hydrolysis under basic condition
  • Ester to Acid (Reduction to Alcohol & Oxidation to aldehyde)
  • Ester to Alcohol using DIBAL-H
  • Ester to Alcohol using LiBH4
  • Ester to Alcohol using NaBH4
  • Ester to Aldehyde using DIBAL-H
  • Functional Group Transformations
  • Functional Group Transformations - Back-up details
  • General Organic Chemistry
  • Green Chemistry
  • Heck Coupling
  • LiAlH4 or LAH reduction of Acids, Esters & Amides
  • Mitsunobu reaction
  • Name Reactions
  • Name Reagents
  • Negishi Coupling
  • Nitrile to Acid using acidic condition
  • Nitrile to Acid using Basic condition
  • Nitrile to Aldehyde using DIBAL-H
  • Nitrile to Amide using UHP (Urea-Hydrogen peroxide)
  • Nitrile to Amine (LiAlH4 or LAH reduction)
  • Nitrile to Amine using Pd/C, H2
  • Nitrile to Amine using Raney Ni, H2
  • Nitrile to Ester using Pinner reaction
  • Other details for website
  • Page template
  • Practical procedures & protocols for Organic Chemists
  • Practical procedures & protocols for Organic Chemists - Back-up details
  • Process Development
  • Protecting Groups
  • SNAr reaction - Cl displacement
  • SNAr reaction - F displacement
  • Sonogashira Coupling
  • Stille Coupling
  • Suzuki-Miyaura Coupling
  • Test page
  • Ullmann Coupling & other Cu Catalyzed reactions

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